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The nonparametric underlying baseline hazards were allowed to differ by study region using the strata option.
This was done using the bootstrap command in Stata using 1000 replications and the strata option to allow for independent sampling within each facility.
To respect the proportional hazards assumption, analyses were performed according to 5-year interval birth cohorts using the STRATA option of SAS PHREG procedure (SAS 9.1.3; SAS Institute, Cary, NC).
Ration was treated as a stratum variable (strata option) to allow for non proportional hazards when comparing the effect of egg size between the two food treatments [88].
Though not presented in the paper, standard errors computed with different bootstrap designs, for instance, without strata option and with a different number of replications also deliver similar results.
In the intrapair analyses, a strata option was included (StataCorp. 2009, Stata Statistical Software: Release 11, College Station, TX, USA and StataCorp LP, College Station, TX, USA).
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Registration through hospital ER's, through general practitioners, through physiotherapists, or through the internet were used as stratum options for the way of enrolment.
The adapted stratified Cox model was implemented by using the R package survival (function coxph, option strata).
The option "–strata" was adopted to make sure that only the highest scoring mapping for a given read was outputted.
The segmentation proposal was then sent to us for our approval; five strata had two segment options.
But because association does not necessarily indicate causation, and to determine if the association observed herein is other than incidental, such relationship must be tested using other study designs, such as public policy-guided interventions abroad and/or with larger samples, as long as comparable age and sex strata and drug therapy options are considered.
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