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If there were only health centres from one strata available (e.g. if all health centres had short history of ART services), we randomly sampled only one health centre for that network; these data are used for this study.
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When we repeated analyses stratified by whether the index child was the first born or second or greater and by parental age (less than 25 years versus > = 25 at birth of child) the results were essentially identical in each strata (results available from authors on request).
All associations generated across the strata are available in Supplemental Material, Files S3 and S4 ("Spreadsheet").
First, we conducted meta-analyses for all the strata with available effect estimates.
p values and odds ratios (OR) of each novel SNP association in individual HLA haplotype strata are available in Supplementary Tables 2 7.
The selection process involved two phases: 1) we stratified guidelines by topic and by year of publication; when multiple guidelines per strata were available, we randomly selected one; 2) we performed a stratified random sampling of recommendations by guideline topic and by turnover (number of pertinent references linked per recommendation in the updating process).
Due to some missing data, 1,652 questionnaires (840 in the highland stratum and 812 in the lowland stratum) were available for analysis (Table 1).
The identification numbers of primary sampling unit and the strata were not available in this dataset for which an analysis using the complex survey design is not possible.
If part B is positive and the drug is registered, the information about these strata may be available to further inform physician and patient choices.
With five RF and two possible outcomes (yes/no) each, we could generate 32 (= 2) possible different combinations of RF, meaning that we had 32 risk strata for IBR available in the scenario tree model.
It was also tested by the proportions of missing in BMI at baseline across five family income strata that were available at the closest follow-up time point using a χ-test [ 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com