Exact(8)
(C ) Quantification of percent closed for both TRAP1 species ± the strap region.
Both yHsp90 and bHsp90 lack a significant strap sequence and Grp94 clearly has an extended and well-conserved strap region.
They demonstrate that the strap region is responsible for a temperature-dependent increase in the rate of TRAP1 closure, as well as the increase in the ATPase activity.
By contrast, Grp94 has a very long and very well conserved strap region, with a somewhat variable, but very acidic N-terminus.
Despite its long size, deleting the analogous strap region in Grp94 accelerates ATP hydrolysis by only fivefold, although temperature modulation was not investigated (Dollins et al., 2007).
These data are consistent with the steady-state SAXS and ATPase and show that removal of the strap region lowers the energy barrier between apo and the closed state.
Similar(52)
He talked about the potential of freshwater reserves from the Nile region in Egypt, and reminded us about the Dead-Red canal, and the project's potential to bring water and energy to the resource strapped region.
Alignments were generated individually for each Hsp90 isoform using a conserved portion of the N-terminal domain and the NTD-strap region.
This alignment clearly shows the divergence of both length and sequence within the NTD-strap region and also reveals that residues are more conserved amongst Hsp90 isoforms within H1 and the region following H1.
[more here] Updated at 4.11pm BST 3.25pm BST Back with Spain, and the government has also approved a new €18bn fund to support the country's 17 cash strapped regions.
In these regions, we explicitly strap the curve to internal points to force it to bend inwards and fill the concavity.
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