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These short, noncoding RNA strands function as negative regulators of gene expression.
G-quadruplexes on DNA strands function as regulators of replication and transcription.
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The exclusion processes that underlie eukaryotic fork leading/lagging strand function are summarized in Figure 8. Pol α primes both leading and lagging strands (diagram A).
Previously, investigation of immortal DNA strand function and molecular mechanisms responsible for their nonrandom co-segregation was precluded by difficulty in identifying DSCs and immortal DNA strands.
Like the DSBR model, recombination by SDSA is initiated at DSBs, and the 3′-end of the invading strand functions as a primer for DNA synthesis (Fig. 1).
Typically, a precursor is cleaved by RNase III family of endonucleases Drosha and Dicer into a duplex: one strand of the duplex is degraded, whereas the other strand functions as mature miRNA [11].
One strand functions as the mature miRNA and is incorporated into the RNA-Induced Silencing Complex (RISC) to target mRNAs for cleavage in a sequence-specific manner.
The MR subgroup is one of the largest subgroups, with a conserved His-Asp dyad located at the ends of the seventh and sixth β-strands functioning as an acid/base catalyst.
There had been some doubt as to whether an ensemble made up of so many disparate strands could function properly, but at the first rehearsal Solti turned to the few people seated in the auditorium and shouted, "It works!" The World Orchestra for Peace was born.
Recent studies have shown that miRNAs can be generated from loop strands and function [ 42, 43].
Yet, this strand transfer function is not as defective as when the same enzyme was used in the strand transfer reaction with preprocessed DNA.
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