This hypothesis is strongly supported by the detection of the outbreak HAV strain in a sample of frozen mixed berries [ 6].
The presence or absence of a gene from the reference strain in a sample strain was decided by majority vote of presence/absence calls of the probes with sequences corresponding to those of the gene.
Bennett et al. (17) found that people who reported job strain spent approximately 1 hour less in physical activities per week, compared with those who did not report job strain in a sample of 1,700 white individuals in Massachusetts.
The pool can be naturally occurring, as in the case of multiple pathogen strains in a blood sample, multiple types of cells in a cancerous tissue sample, or multiple isoforms of mRNA in a cell.
Also, the median ratio of two pneumococcal strains in a given sample was balanced (median 1.3).
The detection of multiple genotypes implies the presence of multiple strains in a clinical sample.
Furthermore, the culture method may not reveal the exact concentration of Mycobacterium strains in a given sample [ 13, 14].
However, ε b, defined in Eq. (1), is not depth-resolved; it refers to a single measurement of the bulk strain present in a sample.
We analyzed M. tuberculosis strain diversity in a sample of 91 isolates from 12 different regions, including northern, central, and southern India, by using a set of 21 VNTR loci, including the 12 MIRU-VNTR loci described previously (17, 18 ) and 9 additional loci containing VNTRs of other interspersed genetic elements (23 – 23 ).
They found that the pathogen strains in all samples were representatives of a single lineage, which they have called HERB-1.
