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This LAM-lineage supremacy conceals a marked multiplicity of distinct clones in the studied strain population.
The Nichols genome was the only one showing variability of this region on a strain population level.
Nevertheless, by distinguishing 321 genotypes in this strain population, combined MIRU-VNTR typing and spoligotyping demonstrated the presence of multiple distinct clones.
Interestingly, similar observations have also recently been obtained in a strain population from another region subjugated by another single M. tuberculosis lineage, i.e. Korea, by the Beijing lineage [58].
Strain population assignment was performed as described by Falush et al [7], using the "no admixture" model in STRUCTURE2.0 [31], the proportion of nucleotides being derived from ancestral population was estimated using the "linkage" model in Structure2.0 as described [7], [26].
However, the applicability of this standardized system has so far not been tested in high TB-burden countries, except in a geographically restricted South African setting with extreme epidemiological conditions [17] or in certain Chinese regions with a specific M. tuberculosis Beijing strain population [18].
Similar(23)
Mixed HCMV strain populations were so far detected in saliva but only rarely in urine of congenitally infected newborns.
These results thus tend to extend conclusions from population-based studies in low incidence settings with different, more assorted strain populations [13], [15], [16].
Each in-silico simulated population was initiated from 100 randomly picked genotypes observed in the single strain populations involved in the migration laboratory experiment.
The rate of occurrence of apoptosis in the different strain populations was measured in two ways.
Furthermore, current MmmSC strain populations may also be shaped by CBPP control strategies based on slaughter and vaccination.
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