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This paper identifies the features of TB control programs that alter the likelihood of novel MDR-TB strain emergence and the extent of spread of newly emerged resistant strains.
We also underscore the importance of male circumcision in the prevention of novel HIV strain emergence.
A major factor that has contributed to increased interest in species-level genetic diversity among pathogenic microbes is the need to understand the molecular basis of biomedically relevant topics such as strain emergence, virulence differences, disease manifestation, and evolution of pathogenic traits.
These results shed light on mechanisms of meningococcal strain emergence.
This study helps illuminate genomic factors associated with meningococcal strain emergence and evolution.
As a result, there should be a new GII.4 strain emergence every 2 to 3 years [ 10].
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H9N2 viruses were predicted to pose a risk of novel-strain emergence due to their: propensity to co-infect with other subtypes, dominance in rLBMs, broad host range, dominance in chickens (the most numerous poultry species), low virulence (i.e., low detectability) and capability of infecting humans [ 5, 13- 15].
We identified genetic variations associated with NPB and brown rot strains emergence.
The ehx plasmids of these strains are highly related, which suggests acquisition of the large plasmid was central to the strains' emergence.
Although we tested only DENV-2 strains, emergence of DENV serotypes 1, 3, and 4 may also have been mediated by vector switching (from infecting sylvatic Aedes mosquitoes to Ae. aegypti and Ae. albopictus).
Since the study of C. trachomatis genes is hampered by the lack of any molecular tools with which to manipulate strains, the emergence of the new variant strain and naturally occurring mutants provides an opportunity to investigate the evolution of the plasmids and to determine whether the evolutionary pathway of these plasmids matches that of the chromosome.
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