Sentence examples for straightforward mechanistic from inspiring English sources

The model's simplicity, the fact that it provides a straightforward mechanistic interpretation in terms of the underlying circuitry, and the scope of the findings both explained and predicted, suggests we should consider this idea seriously as a working hypothesis for the origin of the cortical architecture.

The face-to-face interaction observed in the human Ire1α crystals provides a straightforward mechanistic explanation for how the cytoplasmic kinase domains of two Ire1 molecules, brought into close proximity by the association of their luminal domains on the opposite side of the ER membrane, might achieve transphosphorylation.

Once a reference PBPK model has been established, it can be used to extrapolate between species or individuals outside the selected cohort and allows a straightforward extension to additional mechanistic details such as target-side pharmacokinetic/pharmacodynamic (PK/PD) interaction.

Common to these approaches is the straightforward concept to gain a better mechanistic understanding if the models can well predict known transcript levels after concise selection of putative regulatory information.

The approach of Fig.  1 provides a mechanistic alternative, which it is straightforward to extend to deal with more detailed aspects of plants and crops.

Population genetic analysis is appropriately focused on trait variance; however, from a mechanistic perspective, it is more straightforward to examine each genetic variant in a defined background before reconstructing the entire system.

Surprisingly, the genetic pathways implicated in the DR effect vary depending upon method, suggesting considerable mechanistic complexity for such a seemingly straightforward environmental manipulation.

Although emerging as a conceivable VPA target from a mechanistic point of view, vinculin might be less straightforward to exploit as a biomarker of VPA effects given the weak response in our cell model.

However, the detailed mechanistic interpretation of changes in metabolite abundance is not straightforward, as they may arise from different sources, some of them unlikely to be related with the phenotype of interest.

Despite its limitations, we developed a simple, straightforward and easy-to-use tool for hypothesis building, towards a mechanistic interpretation of experiments, seeing the forest for the trees in a large amount of data.

In part I of applying mechanistic design patterns, the application of the adaptor pattern is very straightforward in the roadrunner portion of the exercise.