While abnormalities in heart rhythms are fairly straightforward to detect, "in the brain, it's much more complicated," says Rezai.
Nevertheless, there are examples of molecular mimicry by linear epitopes which are straightforward to detect by comparative genomics as performed here.
Such variants are easily visualized, relatively straightforward to detect, and have driven many successful studies of the associations between genomic variation and human disease [ 1- 3].
Intramolecular FRET (occurring between donor and acceptor fluorophores on the same host molecule) is straightforward to detect, analyze and interpret due to the presence of fixed acceptor-donor ratios (A D) ratios.
Additionally we demonstrate the feasibility of homologous integration using relatively short 1 kb homology arms that are easy to generate and whose integrations are straightforward to detect by PCR.
Once each folding trajectory is summarized into generalized SOAPs, it is fairly straightforward to detect folding events such as the formation of α-helix or β-turn like local structures.
The four suppressor mutations were straightforward to detect because they led to reversion of dms4-1 mutant phenotypes (that is, the suppressor mutants were GFP− and had a normal developmental phenotype).
16 Because of their formation in limited amounts and the complexity of the samples background, it has not always been straightforward to detect the presence of the unnatural polyketides in the bacterial crude extracts.
Our study has reported point mutations that are comparatively straightforward to detect, but smaller copy number and structural variants (which can be much harder to detect using standard technologies) also may be detectable using whole genome sequencing as recently shown in intellectual disability (Gilissen et al., 2014).
We take advantage of the fact that while predicting genetic interactions a priori from population data may be difficult computationally and of low power, it is much more straightforward to detect epistasis among variants a posteriori once they have been detected [ 38].
