On our pages, this was a brief item – yet its content provides a perfect example of the significant middle-ranking item that can lose out between must-do corrections and the quick straightforward correction.
Furthermore, while interpreting the statistical significance of models fit using traditional methods is fairly straightforward, correction must be made for multiple testing.
This is a straightforward correction approach in the presence of the authentic 5′ss, as demonstrated by the remarkable inhibition of the cryptic 5′ss and rescue of correct splicing obtained with the AON360 in the context of the wild-type and of missense mutants.
To adjust this disparity, we propose a straightforward multiplicative correction factor K R given by {K}_{mathrm{R}} = 0.0141/0.0135 = 1.0396.
Combined with the use of commercially available gene blocks for the efficient generation of HDR constructs, CRISPR-based genome editing is a relatively straightforward technology for correction of genetic mutations in patient-specific cells in vitro.
Although there is no guarantee that Steps 2, 3 and 4 succeed in finding experimental evidence for a correct version, this is the simplest and most straightforward way of error correction.
Cloning and error correction were straightforward, requiring nothing more than transforming competent cells with amplified gene fragments.
Nevertheless, because of the way SNPMaP is implemented, for those users with access to a large reference sample of individuals typed on individual arrays, it is straightforward to apply the correction.
To reduce the high temperature dependence, we apply a simple and straightforward method of linear temperature correction.
MR-based attenuation correction is not straightforward, since the image information provided by MRI is not directly related to tissue density with respect to ionizing radiation as in PET or CT.
