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The proposed approach aims, through a straightforward clustering procedure, to discover automatically the optimal number of clusters, representing the main state conditions of a structural system.
This information can be used for the identification of clefts and surface concavities: A straightforward clustering algorithm is applied to combine neighboring grid points with an appropriate buriedness-index into disjoint groups highlighting those parts of the grid located in less accessible parts of the protein surface (Figure 5b).
A major advantage of MLVA over spa-sequence typing is the straightforward clustering of MLVA profiles compared to that of SpaTypes.
Incredibly, our methods are almost as efficient as straightforward clustering.
First, straightforward clustering of mass spectra, e.g. k-means (McCombie et al., 2005).
Second, our methods significantly outperform the straightforward clustering (Fig. 5C) where strong noise hides details and the whole anatomical regions.
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Previous studies addressing the topic of scalable multi-hop routing have relied on the usage of straightforward clustered network organizations.
Clearly, a straightforward "cluster expansion" makes sense only in a regime of dilute selective sweeps at sufficiently low rates of beneficial mutations, where the interference interactions of Figure 2, C F, are infrequent.
Results shown by Alexandrov et al. (2010) confirm that a procedure taking into account spatial relations between pixels delivers a better quality than a straightforward pixels clustering.
Many papers, theoretical and experimental, have been devoted to demonstrating that spatial environment stabilizes homotypic cooperation, which seems very straightforward: cooperators cluster with their cooperative offspring and cheaters with their cheating offspring, so of course this favors cooperation, especially if other resources are non-limiting.
Although we used a straightforward agglomerative clustering approach to simplify this genome-wide network into functional modules, this was for convenience only and could be refined or replaced to define more precisely delimited pathways for sequestration or variant gene regulation in the in vivo P. falciparum transcriptome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com