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First, nonsymptomatic developmental exposures to parathion straddling the threshold for cholinesterase inhibition nevertheless produce lasting changes in ACh synaptic function.
Neonatal exposure to parathion, at doses straddling the threshold for cholinesterase inhibition, compromises indices of ACh synaptic function in adolescence and adulthood.
For chlorpyrifos, we used daily doses of 1 mg/kg and 5 mg/kg, straddling the threshold for growth retardation and systemic toxicity (Campbell et al. 1997; Whitney et al. 1995).
Here, we evaluated the effects of a brief neonatal parathion exposure at doses straddling the threshold for cholinesterase inhibition and the first signs of toxicity (Slotkin et al. 2006a).
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Doses of 0.1 and 0.2 mg/kg/day were chosen because they straddle the threshold for barely detectable cholinesterase inhibition and the first signs of reduced weight gain or impaired viability (Slotkin et al. 2006a, 2006b).
Neonatal rats were given parathion on postnatal days 1 4 using doses (0.1 or 0.2 mg/kg/day) that straddle the threshold for barely detectable cholinesterase inhibition and the first signs of systemic toxicity.
Doses of 0.5 and 2 mg/kg/day were chosen because they lie below the threshold for signs of systemic toxicity in developing rats, as evidenced by impaired viability or reduced weight gain (Slotkin et al. 2006a), and they straddle the threshold for barely detectable cholinesterase inhibition (Slotkin and Seidler 2007a; Slotkin et al. 2006b).
Here, we evaluated the lasting effects after a brief period of neonatal parathion treatment straddling the dose threshold for the first overt signs of toxicity, as characterized by a loss of viability of approximately 5 10% (Slotkin et al. 2006a).
Neonatal rats received parathion on postnatal days 1-4 at 0.1 or 0.2 mg/kg/day, straddling the cholinesterase inhibition threshold.
Neonatal rats received parathion on postnatal days 1 4 at 0.1 or 0.2 mg/kg/day, straddling the cholinesterase inhibition threshold.
The central box highlights tallies that straddle the classification threshold for the sum. Figure 10 shows the results of applying our beta binomial analysis to the training pool for model logP3-3a.
More suggestions(15)
straddling the border
incorporating the threshold
cross the threshold
straddling the mainstream
straddling the motorbike
straddling the bike
straddling the fence
straddling the line
straddling the beam
straddling the divide
straddling the globe
straddling the middle
straddling the shape
straddling the log
straddling the spine
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com