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Doses of 0.1 and 0.2 mg/kg/day were chosen because they straddle the threshold for barely detectable cholinesterase inhibition and the first signs of impaired viability (Slotkin et al. 2006a, 2006b).
Doses of 0.1 and 0.2 mg/kg/day were chosen because they straddle the threshold for barely detectable cholinesterase inhibition and the first signs of reduced weight gain or impaired viability (Slotkin et al. 2006a, 2006b).
Neonatal rats were given parathion on postnatal days 1 4 using doses (0.1 or 0.2 mg/kg/day) that straddle the threshold for barely detectable cholinesterase inhibition and the first signs of systemic toxicity.
Doses of 0.5 and 2 mg/kg/day were chosen because they lie below the threshold for signs of systemic toxicity in developing rats, as evidenced by impaired viability or reduced weight gain (Slotkin et al. 2006a), and they straddle the threshold for barely detectable cholinesterase inhibition (Slotkin and Seidler 2007a; Slotkin et al. 2006b).
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We compared the consequences of neonatal exposure (postnatal days PN1-4) to diazinon or parathion on development of norepinephrine systems in rat brain, using treatments designed to produce equivalent effects on cholinesterase, straddling the threshold for barely-detectable inhibition.
First, nonsymptomatic developmental exposures to parathion straddling the threshold for cholinesterase inhibition nevertheless produce lasting changes in ACh synaptic function.
Neonatal exposure to parathion, at doses straddling the threshold for cholinesterase inhibition, compromises indices of ACh synaptic function in adolescence and adulthood.
We administered diazinon (DZN) or parathion (PRT) to rats on postnatal days 1 4 at doses straddling the threshold for systemic signs of exposure and assessed the effects on hepatic and cardiac cell signaling mediated through the adenylyl cyclase (AC) cascade.
Here, we evaluated the effects of a brief neonatal parathion exposure at doses straddling the threshold for cholinesterase inhibition and the first signs of toxicity (Slotkin et al. 2006a).
For chlorpyrifos, we used daily doses of 1 mg/kg and 5 mg/kg, straddling the threshold for growth retardation and systemic toxicity (Campbell et al. 1997; Whitney et al. 1995).
The central box highlights tallies that straddle the classification threshold for the sum. Figure 10 shows the results of applying our beta binomial analysis to the training pool for model logP3-3a.
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