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Signalling through PLCγ leads to inositol-1,4,5-triphosphate (IP3) binding to the IP3R-expressing Ca2+ stores and subsequent Ca2+ release.
Two insulin secretion peaks upon glucose stimulation are expected, representing current insulin stores and subsequent insulin production.
PAR2 activation leads to an increase of Ca2+ ions from intracellular calcium stores and subsequent histamine release.
Calcium decreases bone resorption during pregnancy (Janakiraman et al. 2003) and may minimize release of lead from bone stores and subsequent fetal lead exposure (Gomaa et al. 2002).
These involve G protein activation of a signaling complex that elicits release of Ca2+ from intracellular stores and subsequent activation of a transduction channel that depolarizes the membrane to cause transmitter release and the activation of gustatory nerve fibers.
Oxidative stress can trigger the opening of the mitochondrial membrane permeability transition pore (mPTP) and lead to a significant loss of mitochondrial NAD+ stores and subsequent derangement of cellular energy reserves and intact cellular functions.
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The design was encoded using the JSON-LD specification [7] because it is both a human readable and editable format and can easily be converted to RDF [5] triples for ingestion into a triple store and subsequent SPARQL searching [6].
Regulation is achieved, at least in part, by intron retention in the stored RNA and subsequent splicing of retained introns to allow protein production [ 15].
All peripheral tissues and brain were removed, weighed and stored for subsequent protein and RNA extractions or for histological analyses.
Sera, plasma and urine samples will be collected annually and stored for subsequent measurement of renal and cardiovascular-related biomarkers related to multiple pathways involving early AKI.
Dried samples were then stored at −80 °C until derivatization and subsequent analyses.
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