Sentence examples for storage of cholesterol from inspiring English sources

These studies showed no significant differences in onset of clinical disease, in longevity, or in storage of cholesterol and GSLs between Npc1−/− mice receiving allopregnanolone in DMSO or corn oil compared to vehicle-only controls.

Consistent with this scenario, a recent study in which functional NPC1 protein was expressed in an astrocyte-specific manner in Npc1−/− mice was reported to lead to increased longevity and decreased neuronal storage of cholesterol [44].

Since onset of clinically-evident brain dysfunction is documented to occur later in life for both mouse models (>5 mos) [31] [33], analysis was limited to changes in brain storage of cholesterol and gangliosides.

Moreover, 25HC was shown to be more potent than cholesterol in stimulating cells to respond to high sterol levels either decreasing 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity or by increasing cholesterol esterification, thereby leading to a decreased synthesis and/or augmented storage of cholesterol [50].

By contrast, one single week of early treatment from P7 to P14 or P14 to P21 did not result in decreased levels in an end-stage mouse (Fig. 7B), a result consistent with the massive storage of cholesterol and sphingomyelin observed in the livers of those mice (Fig. S4).

Marf is required to form contacts between the endoplasmic reticulum and/or lipid droplets (LDs) and for proper storage of cholesterol and ecdysone synthesis in ring glands.

One study has investigated the effect of long-term storage on cholesterol levels for up to seven years of storage.

Filipin staining displayed storage of free cholesterol exclusively in the subiculum of LAMP-2-deficient mice.

To investigate the effect of endosomal/lysosomal storage of unesterified cholesterol on Il6 mRNA expression and secretion, primary wild-type osteoblasts were cultured in the presence of 0.3 or 3.0 µg/ml U18666A (Sigma) for 6 h.

If the body is deprived of food for a short time, it shuts down the production and storage of fat and cholesterol and shifts to using stored fats as the primary source of energy.

Furthermore, a number of defects related to the storage of triglycerides and cholesterol were identified in hepatocytes from PDE3B KO mice.