Sentence examples for stopping boundaries from inspiring English sources

Simulation is used to assess the accuracy of both methods for various stopping boundaries and numbers of interim analyses.

In the sequential analysis of data, both Bayesian and frequentist methods often make use of stopping rules or stopping boundaries.

In this manuscript, we propose a simple method of searching stopping boundaries of both hypotheses simultaneously that satisfy α and β constrains using binomial distribution.

Here, we discuss an alternative method based on Monte Carlo simulation that allows the group size and stopping boundaries of a multi-arm multi-stage t-test to be optimised, according to some nominated optimality criteria.

To allow for unknown variance, previous research explored the performance of t-test statistics, coupled with a quantile substitution procedure for modifying the stopping boundaries, at controlling the familywise error-rate to the nominal level.

However three issues remain unclear to investigators: 1) among several BRAR algorithms, how to choose one for the specific trial setting; 2) when to start and how frequently to update the allocation ratio; and 3) how to choose the interim analyses stopping boundaries to preserve the type 1 error.

A stopping boundary was not determined beforehand.

The stopping boundary for the interim analysis will be based on the Haybittle-Peto approach (32, 33).

The efficacy value of p1 was found smaller than the stopping boundary of α1 = 0.01 pre-defined in the protocol.

The enrollment would be stopped when p values regarding INH-DILI in slow acetylators were less than O'Brien-Fleming type stopping boundary determined by Lan-DeMets approach.

The trial was unblinded in 2003 because DFS values were met (stopping boundary nominal significance, P = 0.0008) and patients were given the opportunity to cross over.