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Chemotherapy was stopped in cases of disease progression or prohibitive toxicity.
Radiation was only stopped in cases of grade 4 hematologic or non-hematologic toxicity until toxicity resolved to at least grade 3. Response to chemoradiation was clinically and cytologically evaluated at the third month after ending treatment.
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Stop in case of convergence, otherwise, repeat from step 3. .
Dogs received regular breaks and observations were stopped in case the dogs showed any sign of severe stress.
eThis sequential re-initialization process is stopped in case the best solution found for both problems does not improve for more than three consecutive iterations.
Treatment was stopped in case of intolerable toxicity or disease progression.
Oxaliplatin was stopped in case of grade 3 or 4 peripheral sensory neuropathy.
Chemotherapy was stopped in case of symptomatic heart failure and creatinine serum level >150 μmol l−1.
IFN-α2b will be stopped in case of grade 4 haematological toxicities.
Treatment was stopped in case of grade 4 mucositis, diarrhoea, or hand-foot syndrome.
Both chemotherapy regimens were stopped in case of disease progression, unacceptable toxicity or patient refusal.
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