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A gene that stopped cell proliferation, for example, could be potentially harmful if expressed in liver, lung, or other cells.
As expected, incubation with 1 nM Aplidin™ completely stopped cell proliferation and 5 and 10 nM already induced apoptosis (Fig. 2a).
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hHR23A was knocked down in MAGI-CCR5 cells using siRNA (control cells were treated with control siRNA), cells were transferred from high (10% FBS) to low serum (0.1% FBS) to stop cell proliferation [45] and both proliferating and non-dividing cells were then infected by Vpr-positive (Vpr+) or Vpr-negative (Vpr−) HIV-1Ada.
Although preliminary, results confirmed that FAT1 overexpression affects YAP/TAZ phosphorylation, nuclear localization and transcriptional activity, which may stop cell proliferation and affect cell polarity.
Thymidine (Th) and nocodazol (Noco) stop cell proliferation without any measurable impact on cell survival up to 48 h.
In non-cancer cells, TGFβ stops cell proliferation, induces differentiation, or promotes apoptosis.
The aim of cancer therapies is mainly to stop cell proliferation or induce cell death.
Overexpression of miR-19b might be an attempt to stop cell proliferation.
The dose of 1 mM was selected due to its best efficiency to stop cell proliferation and thus to synchronize cells in G0/G1.
In contrast, the other concertrations of chemotherapy drugs would kill all tumor cells or would not stop cell proliferation in our study.
As RA upregulates FR- β in AML cells like KG1 cells [ 9], plays an important role in the regulation of cell differentiation, and stops cell proliferation, it was used as the hydrophobic core of the micelles.
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