Exact(1)
Recently, the Selenium and Vitamin E Cancer Prevention Trial (SELECT), a mega-trial aimed to evaluate the efficacy of selenium in preventing prostate cancer, was prematurely stopped by the data and safety monitoring committee because of lack of benefit on the primary end point and the possibility of an increased risk of diabetes in the selenium-only arm (Lippman et al. 2009).
Similar(59)
Particular attention was given to patient neutrophil counts, with enrollment into the study to be stopped by the data-monitoring committee if an increased rate of neutropenia was observed.
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At the point the data dredging is stopped (by the investigator, or by the computer), the best model is at high risk to fit only the data at hand, and hence cannot be used for prediction.
"I was stopped by the color barrier".
Due to the life-threatening events in these two cases, enrollment was stopped by the Data and Safety Monitoring Board (DSMB).
The study was stopped by the Data Monitoring Board at the first interim analysis for futility following 279 patients who received the study drug.
This trial originally aimed to enroll 672 patients; however, it was stopped by the Data Safety Monitoring Board after enrolment of 82 patients due to a trend towards increased mortality in the aggressive treatment group.
The reaction was stopped by the addition of Stop Solution.
The trial was stopped early by the data monitoring committee, and the evidence of superiority was unequivocal.
The study was stopped prematurely by the data safety monitoring board for ethical reasons.
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