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Likewise, close monitoring should be performed at the end of the season to note when it is appropriate to stop dosing.
(In September 2010, Roche decided to stop dosing patients in the taspoglutide phase 3 trials because higher than expected discontinuation rates of taspoglutide-treated patients were observed, mainly due to gastrointestinal tolerability and the implementation of the risk-mitigation plan to address serious hypersensitivity reactions.
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The singles from the album included "By the Way", "The Zephyr Song", "Can't Stop", "Dosed" and "Universally Speaking".
Scientists have found that bacteria in a group of Canadian pigs remained mostly impervious to two antibiotics years after farmers stopped dosing the animals.
Open phase improvement was unlikely due to prophylactic treatment changes because in four out of six responders, this treatment was stopped, dose-decreased or unchanged.
The MTD is therefore the dose below the stop dose level.
The stop dose was defined as the dose at which two out of three or three out of six patients experienced DLT.
We excluded any stop doses and excluded data sets describing combinations of morphology codes (e.g., "adenoma and carcinoma") if the combined response was ascribed only to the observed response associated with a specific morphology code (e.g., "adenoma" response but zero "carcinoma" response) already accounted for in the data selection.
This model predicted that after stopping dosing at steady state, the average time to reach the lower limit of the normal ALC range (1.0 × 10·µL−1) is approximately 24 and 123 h (1 and 5.1 day) for the doses of 1 and 10 mg respectively.
Stop-dose groups were excluded from trend statistics but were included in pairwise statistics.
Three levels of change on current prescription were defined as drug stopped, dose altered, and new drug started.
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CEO of Professional Science Editing for Scientists @ prosciediting.com