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By contrast, Prilosec and drugs like it bind themselves to the stomach cells that produce acid, keeping them from making any more.
Among them are many millions of older people who develop atrophic gastritis, a loss of acid-producing stomach cells, and those who chronically take acid-lowering drugs like Prilosec, Prevacid and Zantac to control reflux.
A century ago, researchers discovered that some people — most likely including Mary Todd Lincoln — had a condition called pernicious anemia, a deficiency of red blood cells ultimately identified as an autoimmune disease that causes a loss of stomach cells needed for B12 absorption.
The system could, for example, be used to explore the binding between Helicobacter proteins and those in the stomach cells that it attacks, in order to find targets for new drugs to block ulceration.
In view of mucosal erosions occurred after the administration of NSAID, QCT could save stomach cells from injuries.
Inflamed stomach cells produce sLex to flag down help from the body's immune system.
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The scientists found that antibodies to CagA fish out SHP-2 from stomach cell extracts, and vice versa, indicating that the two proteins team up.
The stability analyses by geNorm suggest B2M-GAPDH, as best reference gene combination for 'stomach cancer cell lines'; RPL29-HPRT1, for 'all stomach tissues'; and ACTB-18S rRNA, for 'all stomach cell lines and tissues'.
NormFinder also identified B2M as the best reference gene for 'stomach cancer cell lines', RPL29-B2M for 'all stomach tissues', and 18S rRNA-ACTB for 'all stomach cell lines and tissues'.
The best single reference gene for each group is as follows; 'non-stomach cancer cell lines' - GAPDH (0.036), 'stomach cancer cell lines' - B2M (0.014), 'normal stomach tissues' - RPL29 (0.028), 'tumor stomach tissues' - RPL29 (0.028), 'all stomach tissues' - RPL29 (0.032) and 'all stomach cell lines and tissues' - ACTB (0.029).
For the evaluation of the reference genes in real situation, we chose 'stomach cancer cell lines', 'all stomach tissues' and 'all stomach cell lines and tissues' because cancer researchers' focus on comparing gene expression in normal and tumor tissues as well as stomach originated cancer cell lines for in vitro study.
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