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Moreover, it is general in the sense that it can accommodate a variety of single-cell, deterministic reaction kinetics as well as various stochastic division and partitioning mechanisms.
When sequential pulses of two different DNA analogs were administered after IRI in mice, epithelial cells in damaged nephrons showed co-labeling frequencies consistent with stochastic division of many tubular cells [67].
The effects of stochastic division as well as those of different division and partitioning mechanisms were assessed in these systems, while the comparison of the stochastic model with a continuum model elucidated the significance of cell population heterogeneity even in cases where only the prediction of average properties is of primary interest.
Even if multiple attractors exist, stochastic division might not generate sufficient variation to transition between them.
Even if multiple attractors exist, stochastic division might not generate sufficient variation to allow transition between them.
Furthermore, many Myo19 RNAi cells undergo stochastic division failure a phenotype that can be mimicked using a treatment that blocks mitochondrial fission and rescued by decreasing mitochondrial fusion, implying that mitochondria can physically interfere with cytokinesis.
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(B ) This mechanism results in heteroplasmy variance increasing both due to stochastic partitioning at divisions and due to random turnover.
In other models, the growth of mass is deterministic or stochastic and division occurs when a randomly assigned mass threshold is reached [ 3].
Turnover is generally low during cell divisions, allowing heteroplasmy variance to increase due to stochastic partitioning.
Characterization of the mitochondrial distribution during HeLa cell division showed that, initially, in metaphase, the mitochondria were evenly dispersed within the cytoplasm, supportive of a stochastic partitioning strategy.
We reasoned that activation of an oncogene through microsatellite instability in vivo should better mimic sporadic carcinogenesis because it is stochastic, cell-division-dependent and restricted to individual cells.
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