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The aim of this study was to simulate stochastic development and growth in response to environmental change using GreenLab, an organ level functional-structural model.
In particular, tumour hypoxia seems to arise from the stochastic development of vasculature during tumour growth.
However, this explained only a portion of the total observed variability in IFP, possibly reflecting stochastic development and remodelling of the tumour vasculature.
Contrary to what we would expect in a stochastic development, the distribution of the immune process in type 1 diabetes is inhomogeneous and lobular, with pancreatic lobules that are affected, and lobules that are not [ 14, 15, 19, 24, 25].
Transgenic mice expressing the c-myc proto-oncogene under the control of the CD2-dominant control region show stochastic development of mainly clonal thymic lymphoma with long latency, indicating that cooperative events are needed for the development of the fully malignant phenotype.
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The model was calibrated using a mathematical model of stochastic plant development and growth.
These provide evidence of deterministic rather than stochastic geologic development.
One may add that the more general form of wave function collapse embodied in the Lüder's rule (Busch & Lahti 2009) is likewise a consequence of the general quantum principles governing stochastic time development set forth in section 4, so need not be added as an additional hypothesis.
The late onset and stochastic tumour development suggest that expression of ATX or the EDG-family LPA receptors cooperates with other events such as secondary mutations to generate the full tumourigenic phenotype.
DNA damage accumulation induces severe, stochastic impairment of development and growth, which is most pronounced in NER mutants that are also impaired in their response to ionizing radiation and inter-strand crosslinks.
During development, stochastic promoter switching between active and inactive states results in transcriptional bursts.
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