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Spectrum of Fates is complementary to Brainbow technology: while the stochastic combination of FPs of Brainbow provides a way to distinguish all adjacent cells, SoFa lines can be used to assign fates to all cells.
We do not yet know if the precocious transcription that we observed in mes-4 PGCs represents premature activation of germline-expressed loci, ectopic activation of soma-expressed genes or some stochastic combination of both.
Multiple copies of the cassette in the genome lead to the stochastic combination of expressed fluorescent proteins enabling color barcoding of cells (Höckendorf et al. 2012; Pan et al. 2013).
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However, as Brainbow is based on a technology in which stochastic combinations of FPs are expressed in cells, the colour of the cell does not carry any particular significance.
Thus, the stochastic extrapolative combination can counteract generic instabilities and largely alleviate resonances with a sufficiently strong Langevin heat-bath coupling, estimates for which are derived here based on the fastest and slowest motion periods.
To this end, the efficient processing of large amounts of data and the stochastic load combination by use of available numerical models may assist with the rationalisation of modelling assumptions and support the validation and verification of design and decision making criteria in the context of risk based ship design.
Depending on the particular problem under consideration and the assumptions made in solving it, the optimization problem may be deterministic, stochastic, or a combination of both.
We will model this phenomenon by using an extension of the stochastic model for combination treatments with cross-resistance, first introduced in [59], [60].
It is proposed that the variable phenotype and penetrance of heritable human telomerase deficiencies result from additional environmental, genetic and stochastic factors or combinations thereof.
We used a combination of stochastic differential equations and stochastic simulations to study the behavior of the signaling network as the strength of an external stimulus is varied.
This clonality indicates that, out of many combinations of stochastic events or changes of signaling, only one event combination has initially led to one tumor.
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