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Gq activation leads to the activation of protein kinase C, a potent secretory stimulus in many cell types including enteroendocrine cells (7).
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Among them, temperature and pH responsive mechanisms have been considerably investigated because they are relatively convenient and effective stimuli in many applications.
Inflammatory situation prevails during any tissue injury and MSCs would be exposed to such stimuli in many clinical conditions.
Indeed, this correction has been used to estimate RFs from responses to natural stimuli in many brain areas [9], [11], [27] [31].
First, the junb gene is rapidly induced by a plethora of stimuli in many different cell types, including LPS-stimulated macrophagic and -pre-B linesocytic cell lines [19], [25].
Egr1 and Egr2 were identified as serum-response genes twenty years ago (15- 17), and are induced by diverse mitogenic stimuli in many different cells.
Because the authors have recorded responses to both sets of stimuli in many individual cells they should be able to address this question of whether selective enhancement depends on selective response.
DOI: http://dx.doi.org/10.7554/eLife.07935.002 Microbes such as yeast and bacteria often adopt a specific phenotype in response to an environmental stimulus, and in many cases this phenotype can be retained even after the stimulus has been removed (Ozbudak et al., 2004; Acar et al., 2005; Hu et al., 2012; Williams et al., 2013).
The stimulus package in many areas crossed over into a social program rather than just a stimulus program.
Another undiscussed element is government stimulus -- in many forms.
Weber and Fletcher formalized one of the hallmarks of such relative estimation by showing that the discrimination threshold is a constant fraction of the stimulus intensity in many perceptual systems (k = ∆I/I; where k is a constant, I is intensity and ∆I is just-noticeable difference).
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