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During prolonged presentation of a high contrast stimulus, firing rate progressively decreases with a time course of seconds [29], [31] [36], [71] [73].
After a delay to the first AP firing, wild-type neurons maintain excitability throughout a 500-ms stimulus, firing repeatedly with no decrement in AP size until the end of the stimulus (Figure 4A).
(B ) Single MeA units were grouped based on the pre stimulus firing rate, and the average response selectivity is plotted for units within each of these groups.
Each point indicates an isolated single unit with the most significant (p<0.01, Nonparametric ANOVA) stimulus induced response plotted for the post stimulus firing rate.
For the window 200 ms before onset of the first choice stimulus, firing was significantly greater in the cued-target than the fixed-target task (ANOVA across cells with factors task × hemifield, main effect of task P < 0.001).
Similar(55)
3.1), the process of training changes the input volleys from disorganised fragments of different stimuli firing synchronously (Fig. 9a) to the anti-phase oscillations of each stimulus represented in turn (Fig. 9b).
For the subset of cells for which the model could be cross-validated on responses to novel stimuli (n = 23), the predictions were highly accurate, with correlation coefficients between predicted and actual responses of 0.62±0.09 for the V stimulus and 0.66±0.07 for the VN stimulus (for firing rate in 2 ms bins).
If surround stimuli reduce firing rates for non-preferred orientation stimuli to zero, a fit to those data may yield 'apparently' more narrow tuning curves, as cells cannot exhibit negative firing rates.
Although our analysis indicated an overall general lack of effect of thalamic stimulation on cortical activity, we explored more precisely its potential effect in the immediate post-stimulus firing of each individual recorded neuron.
First, the pre-stimulus firing rate was subtracted from the post-stimulus firing rate of each unit in order to account for differences in baseline firing rates.
With regards to the decrease in cortical firing, the magnitude of change during 10 Hz stimulation was well correlated with the pre-stimulus firing rate (n = 46 neurons; R = 0.78, see Author response image 1).
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