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When stimulated with low-frequency sinusoidal currents, the neuron locks to the input oscillations, firing one burst per stimulus cycle, as shown in Figure 4A.
Phase values were distributed between −π and π, and were linearly transformed to range between 0 and 30, representing time points in each stimulus cycle.
Cross-correlation was used to compute the lags (in TR resolution units i.e. 1.5 sec) within a stimulus cycle at which each voxel correlated best to the frequency of stimulation (i.e. in cochleotopic mapping, its preferred tone).
Whilst not strictly containing energy at a single frequency, this stimulus allowed us to construct transfer functions for the RTC to a single stimulus cycle, thus avoiding the influence of adaptation.
As the stimulus cycle progresses, the applied bundle force reduces to zero (2c) and then increases in the opposite, inhibitory direction producing hyperpolarization, a stereocilium radial increase, isovolumetric shortening (2d), and a further reduction in the tip-link tension that causes additional relaxation of the bundle in the inhibitory direction.
After this, they clicked a "ready" button, which started the next stimulus cycle.
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Clearly, case A switched from HRS to LRS at the seventh cycle, while a similar resistive switching event occurred on the sixth cycle for case B, indicating that case B required less stimulus cycles to attain the formation of continuous conductive filaments.
The minimum motion stimulus cycled at 2 Hz and was presented for 1 sec.
However, the position of perceived AV synchrony did change over time: As the stimulus cycles repeated, the perceived location of AV synchrony started shifting to other positions.
Compared to control trials in which both components were present throughout, these experimental trials had reduced levels of either visual or auditory adaptation leading into the final five stimulus cycles.
As the input frequency increases, more complex patterns are observed: some stimulus cycles are missed, bursts are not necessarily equally spaced, and they contain a variable number of spikes (see examples in supporting Figure S1A).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com