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Although LPS and TNF-α have previously been found to increase proliferation of renal cells in vitro [ 55, 56], neither stimulus altered proliferation in human PKD cells in this study, suggesting that the effects of these agents on NF-κB activation were not mediated through changes in cellular growth.
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Thus, identifying how manipulations of a stimulus alter its percept can help elucidate the neural representation.
However, we found that for a given donor and stimulus, altering the number of cells in a well does not equate linearly to the same overall response when spot counts are converted to spot forming cells per million PBMC.
Experimental findings suggest the possibility of two-way causality, where altered sensory input including enhanced nociceptive/neuropathic stimuli, altered cutaneous and proprioceptive input affects sensorimotor organisation and processes within the CNS, and these changes in turn affect perception, pain, and motor control processes contributing to the pathophysiology of the condition [ 137, 138].
Morphologically, the presence of NMD and/or matrix stimuli altered the shape of SC-derived myotubes (Fig. 3A D).
A recent study has found a correlation between cortical changes and inappropriate response to noxious stimuli, altered body perception and psychological and cognitive manifestations [ 11].
Since inflammation is a hallmark of AAA pathogenesis [ 2], we examined whether inflammatory stimuli altered levels of HOXA4 in cultured human vascular cells.
Open image in new window Figure 1 Exogenous factors including reprogramming factor cocktails and stoichiometry and environmental stimuli alter intracellular signaling pathways and epigenetic repatterning to suppress fibroblast gene expression and promote cardiomyocyte gene expression to enhance direct cardiac reprogramming.
This raises a question of whether mechanical stimuli alter the mechanical behavior of embryonic tissues that are not actively deforming their surroundings.
Further tests (Test 4 6) probed stimuli altering the dependencies in a specific way.
Touch stimuli alter cytoskeletal organization [ 2], which can strongly impact auxin transport [ 7].
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