Sentence examples for stimulatory environment from inspiring English sources

The modern view of activated microglia classifies them into two main categories: a phagocytic phenotype (innate activation) or an antigen presenting phenotype (adaptive activation), as governed by their stimulatory environment.

Importantly, TriMix mRNA induced a T cell attracting and stimulatory environment, resulting in enhanced induction of antigen-specific T cells.

Recent changes in US and European drug regulation have provided a stimulatory environment for paediatric clinical drug trials to be performed [ 1, 2].

This finding could indicate that a potentially different stimulatory environment may be encountered by NK cells interacting with Ab-coated tumor cells as compared to those that engage only immobilized IgG.

In a stimulatory environment, like in an infection, immature DC undergo activation, maturation and acquire the capacity to cross-present exogenous antigens in MHC class I. Particularly, the Toll-like receptor (TLR) family of proteins initiates the DC maturation process upon recognition of conserved pathogen-associated molecular patterns (PAMPs), like LPS or unmethylated CpG oligodeoxynucleotides.

We think that the reason why several other dose-escalation trials were failing is likely to be related to processes occurring during the time between surgery and adjuvant therapy: any wounded site creates a specific stimulatory environment to promote healing, which inadvertently provides remaining cancer cells with strong pro-proliferative, pro-migratory and anti-apoptotic stimuli [ 45, 46].

However, little is as yet known about the co-stimulatory environment in vivo which favours the differentiation and expansion of Foxp3+ Treg cells during these infections.

Little is yet known regarding the co-stimulatory environment that favours the development of Foxp3+ Treg-cell responses during helminth infections.

We further investigated the the effects of BTB on cell growth in the estrogen-stimulatory environment using ER-positive versus ER-negative breast, endometrial, and ovarian cancer cell lines.

This could potentially affect presentation of leukemia antigens to CD4+ T helper cells, hampering development of a stimulatory cytokine environment for anti-leukemia immune responses.

At day 5, the stimulatory inflammatory environment due to this residual bone debris, maintained rather than decreased the number of macrophages present, as an adaptive response to this stimulation.