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Power consumption of a BEC stimulator chip was ideal enough to maintain a stable BEC stimulation for 7 days of culturing inside the incubator.
We cultured NSCs in the form of single cell on coated biphasic current stimulator chip or in the sphere form on uncoated BEC chip under stimulating at 100 Hz with a magnitude of 4, 8, 16 or 32 µA/cm2 for 50 or 200 µs with the experimental scheme (Figure 3A).
This system comprises a fold-and-bond microelectromechanical systems (MEMS) coil for wireless power and data transmission, a BION 1-3 CMOstimulatoror chip, discrete capacitors, as well as a carrier substrate with two platinum stimulating electrodes and interconnections for system assembly.
In this study, we investigated the effects of electrical stimulation by BEC on the proliferation of NSCs using a biphasic electrical current stimulator chip under several different amplitude and duration settings.
Figure 1A shows a circuit diagram of the stimulator chip.
The waveforms of the fabricated BEC stimulator chip were tested.
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The prototype stimulator chips are realized in standard 0.35 μm CMOS technology.
Figure 1B shows a biphasic current stimulator where the stimulator chips, on/off power switch, and switches for parameter settings are installed.
The implanted device included a hermetic titanium case containing a 15-channel stimulator and receiver chip and discrete circuit components.
By minimizing the number of external pumping units for parallel operation, this device allows further miniaturization of on-chip mechanical stimulators for various studies in the field of cellular mechanobiology.
In the meantime, she is working on the myriad challenges of designing a complex electronic device, such as programming a small chip to be placed in the wrist apparatus to enable it to transmit joint-angle information to the implanted stimulator.
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