Skeletal muscle is a heterogeneous tissue that has the ability to rapidly undergo biochemical and physical changes in response to external stimuli, such as appropriate nervous and hormonal stimulations, to adapt to the accompanying functional demands imposed on it.
Living cells are able to sense three-dimensional environmental properties, to integrate biophysical and biochemical stimulations and to adapt to dynamic changes of their physical surroundings for maintaining appropriate biological functions.
When the cultured plates that are seeded with cells are subjected to biomechanical stimulation, cells are forced to adapt to the deformation of the culture plate.
A number of experiments show that the pulsed laser is more conducive to stimulate the body's functional regulation mechanisms [ 18, 19], but this monotonous pulse signal cannot achieve symptomatic treatment, and long-time repeated stimulation will cause the body to adapt and reduce its efficacy.
Particularly the fact that learning processes may alter certain characteristics of GM or WM morphology in different ways, each of them occurring with different shape, strength, and latency14,18, clearly indicates the necessity to apply longitudinal multimodal imaging parameters to adequately map the manifold dynamics of the brain's capacity to adapt to environmental stimulation.
Dynamic regulation of AMPAR by post-translational modifications is one of the key elements that allow the nervous system to adapt to environment stimulations.
A patient's brain often needs to be retrained to adapt to the new stimulation.
Recent experimental data show that transcranial direct current stimulation (tDCS) of the premotor cortex and low-frequency repetitive stimulation of the motor cortex (LFRSM1) restore the excitability of the motor cortex in hemicerebellectomized rats, reinstating the ability of the motor cortex to adapt to sustained peripheral stimulation.
It has been traditionally rationalized that these mechanisms are present in order to enable the signaling system to adapt to constant ligand stimulation [ 18, 40].
It was probably because the stimulation period was too long (>30 s) and the color change along the hue circle at the rate of 24 s per cycle was too slow, which allowed neurons to adapt to the continuous stimulation.
