Exact(22)
In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization.
Consistent with the Stat1 signaling results, IFNγ stimulation strongly induced expression of both target transcripts in 5-week, but not 20-week, lpr splenocytes (Fig. 3C).
T cell stimulation strongly induces glucose uptake and glycolysis, both of which are severely impaired by inhibition of extracellular signal-regulated kinase (ERK), whereas p38 inhibition had a much smaller effect.
Both experiments presented evidence of biological variability as β-actin expression approached 2-fold differences between treated and untreated conditions at contiguous time points following stimulation strongly implicating the effect of experimental treatment on relative gene expression.
BMP2 stimulation strongly induced Smad1/5/8 phosphorylation, which peaked around 30 minutes after stimulation.
In the salmon myocytes multiple cyclins were modulated by IL-1β stimulation strongly suggesting cell cycle activity is being altered.
Similar(38)
The fMRI results revealed that TM stimulation most strongly activated the pregenual anterior cingulate cortex (pgACC).
While HAF and HSP70 were not regulated by Notch1 ICD (data not shown), we found that CHIP, which encodes a ubiquitin ligase involved in HIF1a degradation, was moderately upregulated by Jagged1 immobilized ligand stimulation and strongly reduced by DAPT (Supplementary Figure 3A), making it a candidate mediator between Notch and HIF1α regulation.
Prefrontal responses to the onset of cold stimulation were strongly related to the subsequent DNIC effect.
S1P-induced hypersensitivity to thermal stimulation was strongly reduced in mice lacking either TRPV1 channels or neuronally expressed S1P1 receptors.
As expected, the FRET changes triggered by anti-CD3 stimulation were strongly inhibited in cells pretreated with PP2 for 30 minutes before stimulation (data not shown).
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