No changes in the thresholds for brain stimulation reward were observed.
Initial studies using this method to assess brain stimulation reward (BSR) examined the enhancement of response rates after drug administration.
The present experiments were designed to determine the role of GABAB receptor function on brain stimulation reward.
In the rat, the ability of drugs to lower brain stimulation reward (BSR) thresholds often correlates with high abuse liability.
In a first study, we tested the effects of three doses of quetiapine (5, 10, 20 mg/kg) on brain stimulation reward using a within-subject design and the curve-shift method.
Changes in hedonic status were indexed for three weeks following a three week baseline period using two standard behavioral measures of anhedonia: sucrose intake and preference and thresholds for brain stimulation reward.
The cyclical pattern of estrous was altered in both strains with a significant reduction in the number of regular cycles as a consequence of both the stressors and brain stimulation reward.
The present study was designed to contrast l-THP's effects on cocaine self-administration under fixed-ratio (FR) and progressive-ratio (PR) reinforcement, and to study l-THP's effects on cocaine-enhanced brain stimulation reward (BSR).
Sites within the habenula support self-stimulation [60], [61] and lesions of the habenula attenuate brain stimulation reward [62].
These stimuli are usually understood as conditioned distal cues that have acquired the motivational properties of primary rewards (e.g., nutrients contained in food, brain stimulation reward and drug rewards) through associative learning [1] [3].
