We observed a significant decrease of telomerase expression with aging (Fig. 6C), confirming our previous results.
The inefficient activation of telomerase expression in oldest fish might be responsible for this behaviour.
In this study, we have also established that there is a direct relation between the levels of telomerase expression, telomerase activity and telomere length in zebrafish.
They concluded that even in glioblastomas that show positivity for telomerase expression, there is variability in the level of telomerase expression from region to region within the tumour.
Deregulation of telomerase expression in somatic cells may be involved in oncogenesis.
Figure 4B shows activity assays from cell lines with different levels of telomerase expression.
For example, is this level of telomerase expression sufficient for immortality?
Deregulation of telomerase expression has been directly linked to human diseases, including cancer.
Thus, the biological and potential medical consequences of telomerase expression appear to be highly significant.
These results indicate that the stabilising effect of telomerase expression on the tumour genom is incomplete.
Nakashio et al. previously reported the significant correlation of HCC differentiation with telomerase expression [ 44].
