Sentence examples for stimulation expansion from inspiring English sources
When lymphocytes were subjected to DC-Tuper stimulation, expansion was observed.
Stimulation, expansion and culture of specific rat T-cells were conducted under conditions described in [ 20].
Stimulation, expansion and culture of specific rat T cells were conducted as described (Flügel et al., 1999).
Chronic immune activation is a hallmark of HIV-1 pathogenesis and may play a role in B-cell stimulation and expansion of EBV-infected cells.
Instead of developing an alternative to pre-existing T cell manufacturing methods, the major goal of this study was to establish a stimulation and expansion platform upon which T cell quality could be easily improved to meet the required phenotypic characteristics, homing capacities, and potent effector functions for effective cancer immunotherapy (Rosenberg, 2008).
To further improve the OKT3/IL-2-based T cell manufacturing procedure, we developed a novel T cell stimulation and expansion method in which peripheral blood mononuclear cells were electroporated with mRNA encoding a chimeric membrane protein consisting of a single-chain variable fragment against CD3 and the intracellular domains of CD28 and 4-1BB (OKT3-28BB).
To further improve the T cell manufacturing procedure, we developed a novel T cell stimulation and expansion method in which PBMCs were electroporated with RNA encoding a chimeric membrane protein consisting of an scFv against CD3 and the intracellular domains of CD28 and 4-1BB (OKT3-28BB).
In addition, stimulated CD4+CD25hi cells isolated at day 0 was included in the experiment to show whether thymus derived T regulatory cells would maintain a demethylated FOXP3 promoter during the course of stimulation and expansion.
In addition, T-cell activation is also scrutinized for immunotherapeutic applications such as adoptive cell transfer, which achieves T-cell stimulation and expansion ex vivo before transferring them back to the patient.
CD40 is usually present on the membrane of APCs and CD40 ligand on activated CD4+/CD8+ T cells, where it transduces signals for their stimulation and expansion.
The current view posits that triggering of asynchronous release during repetitive stimulation involves expansion of the same calcium domains underlying synchronous transmission.
