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In skeletal muscle, the binding of insulin or insulin growth factor-1 (IGF1) activates the phosphoinositol-3 kinase/protein kinase B (PI3K/AKT) pathway inducing muscle synthesis by stimulating translation via mammalian target of rapamycin (mTOR) kinases [23].
In addition, IGF-1 has a direct effect on protein synthesis mainly by stimulating translation (Philippou et al., 2007).
However, the cytoplasmic pool could have an oncogenic role by stimulating translation and proliferation by binding to the eIF4A initiation factor (Wolf et al, 2010).
miRNAs have the ability to form autoregulatory loops and can attract a variety of activities to their targets - even stimulating translation [ 25].
Based on the qRT-PCR data, we hypothesized that LDN-76070 affects transcription, while LDN-75654 functions at the post-transcriptional level either by stimulating translation or stabilizing SMN protein.
The action of PKCβII in stimulating translation is thought to arise, at least in part, from its phosphorylation of eukaryotic initiation factor 6 (eIF6) bound to the 60S ribosomal subunit.
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In addition, a eukaryotic relative of ClpX, the HSP101 heat shock protein of plants specifically binds to and stimulates translation of the A-rich 5' un-translated leader of the tobacco mosaic virus [45].
mTOR directly phosphorylates the 4E-BPs (eIF4E-binding proteins), which are inhibitors of eIF4E, to relieve translational suppression, whereas Mnk phosphorylates eIF4E to stimulate translation.
It also causes post-translational modifications of proteins (Secombe & Eisenman, 2007), stimulates translation (Barna et al, 2008) and plays a role in DNA replication (Dominguez-Sola et al, 2007).
The marqués de Santillana a poet, scholar, soldier, and statesman collected masterpieces of foreign literatures and stimulated translation.
Eukaryotic initiation factor (eIF) 4A is a DEAD-box helicase that stimulates translation initiation by unwinding mRNA secondary structure.
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