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The number of T-cell stimulating sequences involved in CD (9 mer epitope cores) found in a set of 717 γ-gliadin transcripts from T. aestivum (genome ABD) attributed to respectively Gli-A1 (topology group 6 and 7), Gli-B1 (topology group 3, 5, and 8) and Gli-D1 (topology group 9 and10).
While they each offer slick, visually stimulating sequences of death and destruction, one seems a sleekly-made yet unnecessary remake (Dragon) and the other an almost too-peculiar re-imagining (Holmes).
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An example of such an interrogative approach uses a three pulse stimulated sequence necessary to probe a gradient resolved voxel.
Incubation of latent p53 with USP7 in EMSAs stimulated sequence-specific DNA binding by latent p53, suggesting that USP7-binding can reverse this autoinhibition.
Surprisingly the USP7-NTD did not stimulate sequence-specific DNA binding by p5382 393, as the p53-DNA complexes migrated as smears rather than discreet bands both in the presence and absence of the USP7-NTD (Figure 2B).
Similar to what we observed with full-length USP7, the USP7-CTD stimulated sequence-specific DNA binding by p53, as compared to the BSA control, suggesting that it is largely responsible for the p53-USP7 inthatction that results in increased p53 sequence-specific DNA binding.
The observation that USP7 stimulates sequence-specific DNA binding by p53 through interaction with the C-terminal regulatory region of p53 further support the notion that this region of p53 is a positive regulator of p53 DNA-binding and p53 function [20].
He told Sylvester that his imagination was stimulated by sequences and that "images breed other images in me".
From the beginning of his career, Bacon preferred to work in series and found that his imagination was stimulated by sequences; as he put it, "images breed other images in me".
The results suggest that the USP7-CTD can also mediate p53 interactions and that this interaction is largely responsible for stimulating the sequence-specific DNA binding activity of p53.
The stimulated echo pulse sequence was used following the recommendation in [ 12, 13].
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