Sentence examples for stimulating resolution from inspiring English sources

Uncovering these novel SPMs emboldened the notion that agonists can quiesce the propagation of inflammation while stimulating resolution.

An appreciation of these endogenous pathways and mediators that control timely resolution opened a new terrain for therapeutic approaches targeted at stimulating resolution of local inflammation.

Therefore, SPMs such as PD1 and RvD1 stimulate resolution of inflammation via multi-level mechanisms that control the catabasis of inflammation and the restoration of tissue homeostasis.

Of note, only treatment of CLP mice with A2MG-E MP led to a significant increase in exudate levels of the pro-resolving RvD1, RvD5 (Chiang et al, 2012) and RvD2 (Spite et al, 2009), lipid mediators that stimulate resolution and preserve immune vigilance in murine sepsis.

The fact that MTA also reduced the expression of MMP13, the interstitial collagenase in rodents, suggests that MTA down-regulates overall tissue remodelling activity, inhibiting fibrosis progression rather than stimulating fibrosis resolution [3].

Unwinding the complex molecular machinery controlling SPM production, and dissecting the pro-resolving from the pro-inflammatory pathways triggered by TLR7 may therefore provide a key to the future treatment of a wide range of chronic and devastating diseases by stimulating endogenous resolution mechanisms.

In light of these findings, it is now critical to understand further the mechanisms underlying this crosstalk between debris clearance and migration if we are to design therapeutics to stimulate macrophage resolution away from areas such as chronic wounds or tumours where levels of debris and cell death may be very high.

This is particularly crucial in the field of neural prosthesis where high resolution stimulating or recording arrays near peripheral nerves or in the brain could dramatically improve the performance of these devices.