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In support of this idea, a genetic circuit of two TFs each stimulating itself (auto-activation) and repressing the activity of the other (mutual inhibition) has been shown to form a tristable dynamical system [ 3].
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In the course of many hundreds of pages of historical essays and first-person reportage from scenes of warfare and intraethnic mayhem, the author explores the hypothesis that "violence stimulates itself, so that digging any legitimate channel only increases the scarlet flow through all the other creek beds that raddle our rock".
"But if the neuron doesn't stimulate itself again within a little more than a second, it's lost that information".
It would be ironic, but not unprecedented, if China were to stimulate itself into a real-estate-fueled banking crisis less than a year after wagging its finger at the West for doing the same thing.
As TNF-α is well-known to stimulate its own production [ 46], we next investigated whether, similarly, TNF-β stimulates itself in chondrocytes by enhancing TNF-β and TNF-β-R production.
Given the location of the DBS electrodes precisely at the site of interest, namely within the pathological basal ganglia circuit itself, it seems most rational to seek potential biomarkers within this region, and, preferably, to record these through the stimulating electrode itself.
These results show that a) the major inhibitory impact of theta burst rTMS occurs directly in the stimulated area itself, and that b) a lower effect on remote, oculomotor areas can be induced.
A blunted insulin stimulated vasodilation itself leads to vasoconstriction and is thereby proatherogenic.
The process is critically controlled by IFN- γ, which does not stimulate CCL5 itself but synergistically amplifies the effect of TNF α.
Moreover, VIP may also be produced in the pituitary itself, stimulating PRL release by autocrine and paracrine mechanisms [ 17].
But online connectivity can still manifest itself in stimulating ways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com