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Our hypothesis that PKG activation in intact cells stimulates the function of cardiac-type KATP channels was supported.
As we have demonstrated here, TORC2-dependent Ypk1-mediated phosphorylation of Lac1 and Lag1 stimulates the function of the ceramide synthase complex.
In addition, DARRP-32 is a known target of calcineurin and CsA treatment stimulates the function of DARPP-32 by modulating its phosphorylation status [ 26, 41].
Granulocyte/macrophage Colony Stimulating Factor (G-CSF) regulates the production of neutrophil G granulocytes and stimulates the function of mature neutrophils [ 90].
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TSH activates the TSH receptor (TSHR) thereby stimulating the function of thyroid follicular cells (thyrocytes) leading to biosynthesis and secretion of thyroid hormones.
This indicates that the glycerol transporters in T. lutea only function under light illumination, which furthermore suggests that photosynthesis may stimulate the function of glycerol transporters; however, the mechanism is still not very clear.
Snf1 promotes the formation of phosphorylated eIF2α by stimulating the function of Gcn2 during histidine starvation of glucose-grown cells.
The ways by which bacterial-derived molecules coordinate peripherally generated Treg are illustrated in work done with Clostridia and Bacteroides fragilis, as both increase the frequency and stimulate the function of colonic Treg.
On the contrary, E2 appears to stimulate the function of both early and late EPCs in vitro from male and female donors [ 14, 15, 33], and its effects on EPCs have also been substantiated in vivo [ 16, 34].
Indeed, collectively, the findings we describe here demonstrate unequivocally that, in addition to up-regulation of SPT, TORC2-Ypk1 exerts direct control on the ceramide synthase step of the sphingolipid biosynthetic pathway by phosphorylating and stimulating the function of the Lac1 and Lag1 subunits of the ceramide synthase complex.
14 Herbal medicine is a therapy that utilises medicinal plants, minerals and animal parts to prevent or cure clinical conditions; it is approved by the WHO as a therapy for the treatment of AOM. 15 16 Herbal medicines reduce the swelling and prevent endotoxin-induced otitis media by stimulating the function of the mucociliary system related to pathogen clearance in experimental research.
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