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Fatty acid infusion stimulates increasing concentration of prostaglandins, potent inflammatory mediators [ 64], and endothelial dysfunction [ 65].
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"This increase in the carbon dioxide level stimulates increased efforts to breath.
The scarcity of oxygen at high altitudes stimulates increased production of hemoglobin and red blood cells, which increases the amount of oxygen transported to the tissues.
It appears that oxidative stress stimulates an increase in BDNF content, which subsequently stimulates increased antioxidant enzyme expression, at least in part via increased NF-κB activation [83,84].
This increase in the carbon dioxide level stimulates increased effort to breathe.
Interestingly, exposure to quercetin stimulates increased CSPα dimerization in CAD cells.
This leads to the hypothesis that it is the process of pathogenesis that stimulates increased dauer formation.
Indeed, the results imply a post-transcriptional switch which stimulates increased SIRT1-ΔExon8 production from a pre-existing pool of immature SIRT1 pre-mRNA during transcriptional inhibition.
Xu [8] also showed by Förster resonance energy transfer (FRET) that SDF1 stimulates increased cAMP levels, and that this can be blocked by inhibition of calmodulin.
The high glycemic load increases glucose availability and stimulates increased glucose-dependent insulin signaling.
Activation of BMP stimulates increased synthesis of CSPGs from astrocytes surrounding the lesion [ 109].
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