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In this study, we found that Wnt5a dose-dependently stimulated the migration of human gastric cancer cells SGC-79011), withethe maximal effect at 100 ng/mL, via enhancing phosphorylation of PI3K/Akt and GSK3β and activating RhoA.
In another study, Tβ4 stimulated the migration of stem cells in hair follicles leading to increased hair growth.
Furthermore, IL-13 stimulated the migration of mouse pulmonary artery smooth muscle cells in transwell assays.
This peptide also stimulated the migration of B16 F10 cells in the Boyden chamber assay.
TFF3 stimulated the migration of breast cancer cells in an in vitro wounding assay (Fig. 7A).
VEGF-A secreted by DJM-1 cells stimulated the migration of HUVEC.
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Granulocyte colony-stimulating factor has also been demonstrated to stimulate the migration of tumour cells derived from patients with head and neck squamous cell carcinoma, with G-CSFR-positive tumours showing increased invasion (Gutschalk et al, 2006).
In contrast to RAD288, the structurally similar RAD289 had no effect on the migration of OECs, which indicates that the binding and activation of the receptor that results in stimulating the migration of OECs is quite specific.
Metal ions (Co2+ and Cr3+) have been shown to stimulate the migration of T lymphocytes but their effects on macrophages motility are still poorly understood.
These agents protect resident fibroblasts and adult stem cells and stimulate the migration of these cells into damaged areas, where they proliferate to form new tissue.
5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosinophils via a selective G-protein coupled receptor, known as the OXE receptor (OXE-R).
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