Sentence examples for stimulated platelet aggregation from inspiring English sources
Firstly, the effect of aspirin (100 mg/kg) on the inhibition of collagen stimulated platelet aggregation was observed in vitro.
However, TMHE inhibited the thrombin stimulated platelet aggregation activity by 31.41 ± 7.84% at the concentration of 1 mg/mL.
Argatroban inhibited the thrombin stimulated platelet aggregation activity by 78.21 ± 3.29% at the concentration of 0.005 mg/mL.
In summary, TMHE prolonged APTT, PT, and TT clotting times, inhibited the thrombin but not ADP or collagen stimulated platelet aggregation, and prolonged the whole bleeding and clotting time, possibly via inhibition of thrombin.
Recently, an in vitro study conducted in rabbit platelets showed that EPA, DPA and DHA inhibited collagen- or arachidonic acid stimulated platelet aggregation in a dose dependent manner, with DPA being the most potent inhibitor and possibly ten times more powerful than EPA in inhibiting platelet aggregation.
Pre-eclampsia has also been characterised by insufficient levels of the vasodilator prostacyclin, and excessive production of thromboxane, a platelet-derived vasoconstrictor which stimulates platelet aggregation [ 47].
In the context of platelet membranes, THBS1 promotes thrombosis in at least two ways: (1) it stimulates platelet aggregation through CD36 receptor-based inhibition of kinase signaling cascades [ 54], and (2) THBS1 acutely counteracts the promotion of blood flow by nitric oxide via binding to another receptor, CD47, on vascular smooth muscle cells [ 55, 56].
It inhibits both clot-bound and circulating thrombin and decreases thrombin-stimulated platelet aggregation [ 7].
Conversely, TXA2 stimulates platelet aggregation and amplifies the response to other platelet agonists [ 34].
Moreover, the tachykinergic system can regulate motility in several cells [ 52], stimulates platelet aggregation [ 124], and is present in many human body fluids such as breast milk, blood, saliva, and cerebrospinal fluid [ 122].
Plasmin is believed to cause platelet aggregation by stimulating platelet degranulation and release of both dense granules, with ADP, and alpha granules, with fibrinogen and von Willebrand factor, which lead to the activation, recruitment, and aggregation of platelets.
