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As reported by Tabata et al. [34, 35], 4 min of the 20-s work to 10-s rest ratio maximally stimulated oxygen consumption and anaerobic capacity; peak VO2 in the final 10 s of the 4-min Tabata was similar to their participants' VO2max, as was the accumulated O2 deficit.
Consistent with our metabolic chamber data in vivo, both basal and norepinephrine (NE) stimulated oxygen consumption tended to be increased in white adipocytes isolated from PeriA Tg mice (Figure S1).
ADP- stimulated oxygen consumption was higher [ Pstrain = 0.0002] in daf-2 e1370) daf-2 e1370a.
The capacity of BA to respond to NE alone or in combination with FFA was quantified by measuring stimulated oxygen consumption rates (OCR) and mitochondrial membrane potential depolarization.
Metformin inhibited ADP but not CCCP stimulated oxygen consumption indicating that the metformin-mediated inhibition of mitochondrial complex I required polarized mitochondria.
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It stimulates oxygen consumption, inhibits basal insulin release and glucose tolerance, and this impaired insulin intolerance occurs prior to the onset of hyperphagia and obesity [49].
Our own work with DMNQ has shown that DMNQ is able to stimulate oxygen consumption in rotenone inhibited sub mitochondrial particles, and that this effect is cyanide sensitive indicating a similar ability (data not shown).
Based on these considerations, we expected that inoculation of semisolid agar media containing various substrates will result in different patterns of band formation depending on the potential of substrates to stimulate oxygen consumption.
Catechol and 4-fluorocatechol did not stimulate oxygen uptake (Table 2).
A reduction of oxygen availability triggers HIF-1 signaling and its down-stream effects are aimed at reducing cellular oxygen consumption and stimulating oxygen delivery [ 39].
It was proposed that the proton leak activity of these more ubiquitous UCPs would result in a mild uncoupling that would decrease proton motive force and stimulate oxygen consumption, thus reducing local oxygen tension and attenuating superoxide production [ 8- 10].
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