The postmeiotic markers (Odf2, Act, and Prm1) [ 6, 15] are stimulated markedly.
In contrast, in the double OSR1185A/185A/SPAK243A/243A knockin cells that lack SPAK/OSR1 activity, we observed an elevated basal activity of Rb+ uptake that was not stimulated markedly further by hypotonic high K+ conditions, suggesting an increase in KCC activity secondary to decreased phosphorylation at Site-2.
The role of monocytes was tested by infusion into the rabbit hindlimb of MCP-1 using osmotic minipumps and it indeed stimulated arteriogenesis markedly [ 77, 78].
Cytokines increase the synthesis of platelet activating factor, stimulate lipolysis, markedly stimulate the expression of adhesion molecules, and upregulate the synthesis and cell surface expression of procoagulant activity in endothelial cells.
Exposure to rapamycin (12 h, 20 nM), which stimulates autophagy, markedly increased LC3-II levels, again to a greater extent in cKO cells.
This renewed our interest in monocytes, especially since we found that porcine hearts challenged with micro-embolism (Mohri in [ 120]) to stimulate angiogenesis markedly up-regulated the chemo-attractant JE, later called MCP-1, (monocyte chemo-attractant protein1) [ 78, 157, 165].
We choose AtAPC2 for a more detailed analysis of the proposed ATP-Ca transport because ATP uptake of this transporter was markedly stimulated by Ca2+and particularly because Ca2+ stimulation was only slightly affected by Mg2+ presence (Fig. 2).
The role of monocytes was further strengthened by experiments showing that the monocyte stimulant LPS, a Toll-like receptor ligand, markedly stimulated arteriogenesis [ 3] and over-expressed TNF-α [ 2, 68] but that reduction of blood monocyte count with 5′-fluoro-uracil inhibited arteriogenesis [ 2, 59].
This was further confirmed by demonstrating that addition of iron chelators markedly inhibited EEF development in a dose-dependent manner, whereas supplementation with iron markedly stimulated development.
The metabolism of L. zeae is markedly stimulated by the co-culture partner independent of nutrient limitations and experimental setup.
Hepatic de novo lipogenesis (DNL) is markedly stimulated in humans by low-fat diets enriched in simple sugars.
