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No significant difference was noted in stimulated flow rate, pH at rest and buffer capacity during the 1-year observation period.
Peros et al. [6] found that salivary pH and stimulated flow rate significantly increase after, respectively, 12 and 18 weeks of fixed orthodontic treatment while buffer capacity remains almost unchanged after 18 weeks if compared to the baseline assessment.
The stimulated flow rate of whole saliva decreased with increasing histopathological grade.
The resting salivary rate was reduced in subjects with complaints but the severity of reduction was minor relative to stimulated flow rate.
These findings are in agreement with that of Loesche et al [ 26] who found stimulated flow rate to be lower in those complaining of oral dryness.
For measurement of stimulated flow, subjects rinsed their mouth with 1 ml of lemon juice followed by a second rinse with distilled water.
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The donor chewed on a small piece of laboratory self-sealing film (Parafilm, Bermis Flexible Packaging, Neenah, USA) (approximately 5 cm × 5 cm) to stimulate flow of saliva over a period of 10 min.
To study whether the reduced SG inflammation after ICAM-1/Fc treatment affected the salivary flow, we measured stimulated salivary flow at the end of study (age 20 weeks).
We examined basal and stimulated salivary flow and basal tear flow (Schirmer's tear test), and we measured NOx levels in saliva (Table 3).
Pilocarpine stimulated saliva flow rate (SFR) and tear flow rate (TFR) collection was performed as described previously [ 8] at the indicated time points.
It has been stated that SM/SL glands are affected earlier by SS than the parotid glands due to an average reduction of stimulated SM/SL flow rate preceding that of the stimulated parotid flow rate [ 40, 42].
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