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Following chemotherapy and/or the administration of growth factors, such as granulocyte-colony stimulated factor (G-CSF), hematopoietic stem cells (HSC) mobilize from bone marrow to peripheral blood.
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OLFM4 is previously recognized as human granulocyte colony stimulating factor stimulated clone-1 with high expression in cancerous tissues [33].
Mouse recombinant macrophage colony stimulating factor (M-CSF) was obtained from R&D systems (Minneapolis, MN).
Recombinant human macrophage colony stimulating factor (M-CSF) was from Peprotech (Rocky Hill, NJ, USA).
Mouse colony stimulating factor (M-CSF) was purchased from Cell Signaling Technologies.
IFN regulatory factor 9. IFN-stimulated gene factor 3. IFN-stimulated response elements.
Granulocyte colony stimulating factor (G-CSF) is a potent stimulator of HPC mobilization.
The study was paid for by Amgen, which makes a widely used colony stimulating factor, Neupogen.
The two drugs -- stem cell factor and granulocyte colony stimulating factor -- stimulated the bone marrow to produce numerous stem cells, which entered the bloodstream, migrated to the damaged heart, and turned into new heart muscle.
Macrophage-colony stimulating factor.
Granulocyte colony stimulating factor.
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