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Even in a first best world, climate policy design needs to navigate a tradeoff between making commitments that are sufficiently credible to stimulate transformation and retaining flexibility to adjust.
RhoA has been implicated in virtually all stages of cancer progression: for example, in vitro, constitutively active RhoA can stimulate transformation [ 115].
It may play a role during tumor cell proliferation and survival; for example, in vitro, constitutively active RhoA was shown to stimulate transformation (Vega and Ridley, 2008).
30, 32 Although some believe that selective destruction of abnormal melanocytes is a means for reducing the number of cells at risk for malignant transformation, it is also possible that laser or other treatments may inadvertently stimulate transformation to melanoma.
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The pro-fibrotic cytokine, Transforming Growth Factor β1 (TGF-β1), stimulates transformation of human lung fibroblasts into myofibroblasts that produce collagen and other extracellular matrix components, a transformation process blocked by JNK inhibition [24].
On the other hand, Smad transcription factors are key mediators of the biological effects of transforming growth factor β1 in PSC, stimulating transformation to a myofibroblastic phenotype and increased ECM synthesis.
These centers are the most probably formed as a result of thermally stimulated transformation of radiation-induced defects at the nc-Si SiO2 nc-Si SiO2
Furthermore, interactions between the rhizosphere and earthworms stimulated transformation of soil P and guano P; the proportional importance of soil microbial biomass P, organic-P and more soluble P fractions were substantially modified.
We showed here that pulse exposure to oxaliplatin stimulated transformation of HepG2 and MHCC97L HCC cells from a typical epithelial phenotype to a spindle-shaped mesenchymal phenotype, accompanied by the loss of E-cadherin and upregulation of N-cadherin and vimentin.
By introducing Eu element on Ga2O3 host material, it was expected that it will be able to stimulate the transformation structure from a single crystal to poly-crystal structures.
Overexpression of AZI has been demonstrated to enhance cell proliferation and stimulate cell transformation [34], [40], [41].
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