Exact(10)
Taken together, these data suggest that SPHK1 acts to stimulate survival and anti-apoptotic signaling in glioma cells.
To conclude, we found Bcl-2 and Bcl-xL stimulate survival autophagy, and help the formation of autophagosomes through non redundant mechanisms, Bcl-xL acting on the whole independently of Beclin 1.
This is consistent with the loss of AR-mediated growth suppression providing a selective growth advantage, even without the simultaneous acquisition of a gain-of-function ability of AR signaling to stimulate survival and proliferation.
This raises the possibility, that activation of this compensatory feedback loop could thereby stimulate survival of cardiomyocytes.
Multiple studies demonstrated that leptin is able to stimulate survival [ 12- 14], proliferation [ 15- 17], migration and invasiveness [ 18- 22] of several cancer cell types.
β4-Integrin can activate the PI3K pathway and thus stimulate survival and proliferation in the newly arrived cells in the lung.
Similar(50)
In pancreatic β-cells, GLP-1 reduced apoptosis, stimulated survival and proliferation, and increased insulin secretion [ 151].
GP88 overexpression, or exogenous addition blocked the inhibitory effect of letrozole on proliferation, and stimulated survival and soft agar colony formation.
This proposition was of interest since it has been shown earlier that extracellular S100A4 stimulated survival of neurons and the viability of cardiac myocytes [ 18, 34].
Compensatory mechanisms and pro-survial pathways might play a role in maintaining cardiomyocyte function in a damaged heart, at least until the extent of damage overwhelms the potential for stimulated survival.
Although HIF-1 predominantly stimulates survival through various biological processes, proapoptotic signaling may also occur in the presence of DNA damage via p53-mediated activation of proapoptotic BCL2-family members that are upregulated by HIF-1.
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