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This is a specific receptor for hyaluronic acid (HA), and HA is known to stimulate spreading, migration, invasion, and metastasis of cancer cells [11 14, 17].
Phosphorylated paxillin binds to the adaptor protein Crkll, which, in turn, binds to an atypical Rac GEF complex, DOCK180/ELMO, and p130Cas to stimulate spreading by activating Rac1.
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Prolonged incubation of THP-1 cells with PMap stimulated spreading of the cells on a fibronectin surface.
SkQ1 stimulated spreading of granulation tissue over the wounded area accelerating collagen fibers formation and maturation in old mice (Figs. 2, 3).
To explore the roles of the RPEL-repeat and PP1-binding domains, we made actin-binding and PP1-binding deficient mutants and tested their ability to stimulate cell spreading.
HGF is also known to stimulate cell spreading (Matsumoto et al, 1994).
Chondroitin sulfate is able to induce FGF-2-mediated controloliferation, cellrol cell adhesion, and stimulate cell spreading and migration by activating focal adhesion of growth factor [ 28, 29].
Scapinin expression stimulated cell spreading and motility.
In these cells, expression of scapinin stimulated cell spreading and motility.
For example, over expression of syndecan-1 in syndecan deficient Raji lymphoblastoid or COS-7 cells stimulated cell spreading [30].
Expression of GFP-scapinin (wild type) also stimulated cell spreading, but mutation in the RPEL-repeat domain abolished both the actin binding and the cell spreading activity.
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